Search results for "Delirium tremens"

showing 2 items of 2 documents

GRIN1 locus may modify the susceptibility to seizures during alcohol withdrawal

2005

N-Methyl-D-aspartate (NMDA) receptors, members of the glutamate receptor channel superfamily, are generally inhibited by alcohol. The expression and alternative splicing of the obligatory NR1 subunit is altered by alcohol exposure, emphasizing the involvement of the NR1 subunit, which is coded by the GRIN1 gene, in alcohol-mediated effects. We performed an association study in patients with alcohol dependence with the GRIN1 locus. Two independent case control samples consisting of a total of 442 alcohol-dependent patients and 442 unrelated controls were included. There was no overall difference in allele or genotype frequency between patients and controls. However, the 2108A allele and A-co…

Geneticsmedicine.medical_specialtyDelirium tremensbiologyAlcohol dependenceGRIN1Locus (genetics)medicine.diseaseGenotype frequencyCellular and Molecular NeurosciencePsychiatry and Mental healthEpilepsyEndocrinologyInternal medicineGenotypemedicinebiology.proteinAlleleGenetics (clinical)American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
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Polymorphisms in the N-methyl-D-aspartate receptor 1 and 2B subunits are associated with alcoholism-related traits.

2003

Abstract Background This study examined the hypothesis that allelic variants of the ionotropic glutamatergic N-methyl-D-aspartate receptor (NMDAR) are associated with vulnerability to alcoholism and some related traits. Methods We investigated the silent G2108A and C2664T polymorphisms of the NMDAR1 and the NMDAR2B genes, respectively. The case control study included 367 alcoholic and 335 control subjects of German origin. The family-based study comprised 81 Polish alcoholic patients and their parents using the transmission disequilibrium test. Results The genotype frequencies of the NMDAR1 polymorphism differed significantly between control and alcoholic subjects. This difference was also …

AdultMalemedicine.medical_specialtyGenotypePolymerase Chain ReactionReceptors N-Methyl-D-AspartateGene FrequencyPolymorphism (computer science)Internal medicineGenotypemedicineHumansAlleleBiological PsychiatryAllelesGeneticsDelirium tremensPolymorphism GeneticbiologyCase-control studyGRIN1Transmission disequilibrium testMiddle Agedmedicine.diseaseGenotype frequencyAlcoholismEndocrinologyCase-Control Studiesbiology.proteinFemalePolymorphism Restriction Fragment LengthBiological psychiatry
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